It is characterized clinically by slack skin, plaques, nodules, and histologically by granuloma with lymphoid cell infiltrate and multinucleate giant cells with loss of elastic fibers. 病理特点为皮肤的淋巴样细胞浸润及巨大的多核细胞性肉芽肿伴弹性纤维消失。
Results: VEGF and CD34 were expressed in all cases of GCT investigated. VEGF was presented in spindle shaped stromal like tumor cells and osteoclast like multinucleate giant cells. 结果:VEGF在40例GCT中,无论是梭形的基质细胞,还是多核巨细胞均有表达,Ⅲ期的骨巨细胞瘤VEGF的表达明显高于第Ⅰ/Ⅱ期的GCT;
Activities of AKP in the round granular, deltaic fan-like and multinucleate subtegumental cells were weaker in cytoplasm and stronger in the nucleus, while those in the clustered polygonal cells being stronger in cytoplasm, and in the flagellated cells stronger in both nucleus and flagellum part. 圆颗粒细胞、三角扇形细胞及合胞体的AKP活性细胞质较细胞核弱,团簇状排列的细胞主要分布在细胞质,而鞭毛形细胞则集中于细胞核和鞭毛部位;
Further analysis demonstrated cytoskeletal abnormality of multinucleate giant cells. 骨架分析进一步显示,多核大细胞的骨架发生异常。
Appearance and Change of Heat Induced Multinucleate Cells in Seminiferous Epithelium in Rat Testis 热诱导大鼠睾丸生精上皮多核细胞的出现和变化